The following essay explores the connection between pandemic dystopian fiction and a pedagogy of discomfort through a critical reading of The White Plague by Frank Herbert. It is advocated in this essay that a critical reading of the novel can give rise to uncomfortable topics related to living in a pandemic reality, which in turn can be incorporated in an ESL setting to encourage critical inquiry and action. Grounded in a thematic analysis of the novel, it is demonstrated that The White Plague can be used to discuss uncomfortable topics such as fear of biogenetic engineering, fear of others, nationalism, national identity, deglobalisation, violence against women, patriarchy, and traditional gender roles. Contextualised withincontemporary history, tradition, ideology, and recontextualised with the current COVID-19 pandemic, the essay confirms that a critical reading of The White Plague carries the potential to promote a pedagogy of discomfort inside an ESL classroom.