Background: Stress-related disorders are increasing in western societies and are the main reason for sick-leave in Sweden. Previous research justifies occupation-based interventions to increase health and work ability. Aim: To investigate if the occupation-based intervention ReDO (TM)-10 predicts work ability for women at risk for or on sick-leave. Material and Methods: A longitudinal cohort study design including the REDOTM -10. The participants answered a questionnaire about their perceptions of health, work ability, occupational balance, occupational values and mastery at baseline, after intervention and at 12 months follow-up. Differences before and after the intervention as well as at 12 months follow-up and possible predictors of work ability were analyzed. Results: Eighty-six women (response rate 70%) answered the questionnaire at follow-up. Perceived health, occupational balance, occupational value, mastery and work ability were improved after intervention. Perceived health, mastery and socio-symbolic value predicted work ability. Conclusion: The intervention increased perceived health and perceived health predicted work ability. However, the occupational aspects in the intervention did not predict work ability. For the intervention to predict work ability, the work placement might be necessary.