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Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET
Turku PET Centre, University of Turku, Turku, Finland & Department of Medical Physics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Turku PET Centre, University of Turku, Turku, Finland.
Turku PET Centre, University of Turku, Turku, Finland.
Turku PET Centre, University of Turku, Turku, Finland.
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2019 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 10, article id 741Article in journal (Refereed) Published
Abstract [en]

Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and tested an optimized novel method to measure MBF, OEF, and MVO2 simultaneously both in the RV and LV free wall (FW) using positron emission tomography in healthy young men at rest and during supine bicycle exercise. Results: Resting MBF was not significantly different between the three myocardial regions. Exercise increased MBF in the LVFW and septum, but MBF was lower in the RV compared to septum and LVFW during exercise. Resting OEF was similar between the three different myocardial regions (similar to 70%) and increased in response to exercise similarly in all regions. MVO2 increased approximately two to three times from rest to exercise in all myocardial regions, but was significantly lower in the RV during exercise as compared to septum LVFW. Conclusion: MBF, OEF, and MVO2 can be assessed simultaneously in the RV and LV myocardia at rest and during exercise. Although there are no major differences in the MBF and OEF between LV and RV myocardial regions in the resting myocardium, MVO2 per gram of myocardium appears to be lower the RV in the exercising healthy human heart due to lower mean blood flow. The presented method may provide valuable insights for the assessment of MBF, OEF and MVO2 in hearts in different pathophysiological states.

Place, publisher, year, edition, pages
Lausanne: Frontiers Media S.A., 2019. Vol. 10, article id 741
Keywords [en]
positron emission tomography, myocardial blood flow, myocardial oxygen metabolism, right ventricle, left ventricle
National Category
Physiology
Identifiers
URN: urn:nbn:se:hh:diva-41454DOI: 10.3389/fphys.2019.00741ISI: 000472051600001PubMedID: 31275160Scopus ID: 2-s2.0-85069190505OAI: oai:DiVA.org:hh-41454DiVA, id: diva2:1390225
Funder
Academy of Finland
Note

Other funders: University of Turku, Turku University Hospital, Åbo Academy, Sigrid Juselius Foundation, JSPS KAKENHI (C) Grant Number 26460728 2014–2016 (NK), The Finnish Cardiovascular Foundation, and The Finnish Diabetes Research Foundation.

Available from: 2020-01-31 Created: 2020-01-31 Last updated: 2020-02-06Bibliographically approved

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Heinonen, Ilkka

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