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Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults
School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Western Australia, Australia & Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.ORCID iD: 0000-0002-7404-7069
School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Western Australia, Australia & Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia & Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.ORCID iD: 0000-0003-2629-9568
School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Western Australia, Australia.
School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Perth, Western Australia, Australia & School of Kinesiology, Lakehead University, Thunderbay, Ontario, Canada.ORCID iD: 0000-0002-8914-6457
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2019 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 126, no 4, p. 1049-1055Article in journal (Refereed) Published
Abstract [en]

Preventing declines in cerebral blood flow is important for maintaining optimal brain health with aging. We compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cerebral blood velocity over 8 h in older adults. In a randomized crossover trial, overweight/obese older adults (n = 12, 70 +/- 7 yr; 30.4 +/- 4.3 kg/m2), completed three acute conditions (6-day washout); SIT: prolonged sitting (8 h, control); EX + SIT: sitting (1 h), moderate-intensity walking (30 min), followed by uninterrupted sitting (6.5 h); and EX + BR: sitting (1 h), moderate-intensity walking (30 min), followed by sitting (6.5 h) interrupted with 3 min of light-intensity walking every 30 min. Bilateral middle cerebral artery velocities (MCAv) were determined using transcranial Doppler at 13 time points across the day. The temporal pattern and average MCAv over 8 h was determined. The pattern of MCAv over 8 h was a negative linear trend in SIT (P < 0.001), but a positive quadratic trend in EX + SIT (P < 0.001) and EX + BR (P < 0.01). Afternoon time points in SIT were lower than baseline within condition (P <= 0.001 for all). A morning dip in MCAv was observed in EX + SIT and EX + BR (P < 0.05 relative to baseline), but afternoon time points were not significantly lower than baseline. The average MCAv over 8 h was higher in EX + SIT than SIT (P = 0.007) or EX + BR (P = 0.024). Uninterrupted sitting should be avoided, and moderate-intensity exercise should be encouraged for the daily maintenance of cerebral blood flow in older adults. The clinical implications of maintaining adequate cerebral blood flow include the delivery of vital oxygen and nutrients to the brain.

NEW & NOTEWORTHY: This is the first study to measure the combined effects of an exercise bout with breaks in sitting on cerebral blood velocity in older adults. Using frequent recordings over an 8-h period, we have performed a novel analysis of the pattern of cerebral blood velocity, adjusting for concurrent measures of mean arterial pressure and other potential confounders in a linear mixed effects regression. 

Copyright © 2019 the American Physiological Society.

Place, publisher, year, edition, pages
Rockville: American Physiological Society , 2019. Vol. 126, no 4, p. 1049-1055
Keywords [en]
acute exercise, brain health, older adults, sedentary behavior, transcranial Doppler
National Category
Physiology
Identifiers
URN: urn:nbn:se:hh:diva-41459DOI: 10.1152/japplphysiol.00001.2019ISI: 000465079900026PubMedID: 30730813Scopus ID: 2-s2.0-85064950079OAI: oai:DiVA.org:hh-41459DiVA, id: diva2:1390223
Available from: 2020-01-31 Created: 2020-01-31 Last updated: 2020-02-06Bibliographically approved

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Heinonen, Ilkka

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Wheeler, Michael J.Dunstan, David W.Smith, Kurt J.Scheer, AnnaNaylor, Louise H.Heinonen, IlkkaEllis, Kathryn A.Cerin, Ester
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