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The oncoprotein TBX3 is controlling severity in experimental arthritis
Nordic Bioscience A/S, Copenhagen, Denmark.
Nuritas, Dublin, Ireland.
Karolinska Institutet, Stockholm, Sweden.
IQVIA Denmark, Copenhagen, Denmark.
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2019 (English)In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 21, no 1, article id 16Article in journal (Refereed) Published
Abstract [en]

Background: Development of autoimmune diseases is the result of a complex interplay between hereditary and environmental factors, with multiple genes contributing to the pathogenesis in human disease as well as in experimental models for disease. The T-box protein 3 is a transcriptional repressor essential during early embryonic development, in the formation of bone and additional organ systems, and in tumorigenesis.

Methods: With the aim to find novel genes important for autoimmune inflammation, we have performed genetic studies of collagen-induced arthritis, a mouse experimental model for Rheumatoid Arthritis.

Results: We show that a small genetic fragment on mouse chromosome 5, including Tbx3 and three additional protein-coding genes, is linked to severe arthritis and high titers of anti-collagen antibodies. Gene expression studies have revealed differential expression of Tbx3 in B-cells, where low expression was accompanied by a higher B-cell response upon B-cell receptor stimulation in vitro. Furthermore, we show that serum TBX3 levels rise concomitantly with increasing severity of CIA.

Conclusions: From these results, we suggest that TBX3 is a novel factor important for the regulation of gene transcription in the immune system and that genetic polymorphisms, resulting in lower expression of Tbx3, are contributing to a more severe form of collagen-induced arthritis and high titers of autoantibodies. We also propose TBX3 as a putative diagnostic biomarker for rheumatoid arthritis.

Place, publisher, year, edition, pages
London: BioMed Central, 2019. Vol. 21, no 1, article id 16
Keywords [en]
Collagen-induced arthritis, transcriptional regulation, TBX3, TBX5, biomarker, Eae39r
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:hh:diva-38630DOI: 10.1186/s13075-018-1797-3PubMedID: 30630509OAI: oai:DiVA.org:hh-38630DiVA, id: diva2:1271294
Note

Funding: The Danish Rheumatism Association, The AP Møller Research grant for Medical Science and The Oticon foundation

Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2019-01-14Bibliographically approved

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