Customisable 3D printed microfluidics for integrated analysis and optimisationShow others and affiliations
2016 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 16, no 17, p. 3362-3373Article in journal (Refereed) Published
Abstract [en]
The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels. © The Royal Society of Chemistry 2016.
Place, publisher, year, edition, pages
Cambridge: Royal Society of Chemistry, 2016. Vol. 16, no 17, p. 3362-3373
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:hh:diva-37849DOI: 10.1039/C6LC00562DISI: 000382684100021Scopus ID: 2-s2.0-84983301283OAI: oai:DiVA.org:hh-37849DiVA, id: diva2:1247267
Note
Funding: Engineering and Physical Science Research Council (EPSRC) via the Centre for Innovative Manufacturing in Additive Manufacturing
2018-09-112018-09-112018-09-24Bibliographically approved