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Association between visceral fat, obesity and biomarkers for inflammation in subjects experiencing symptomatic knee pain
Halmstad University, School of Business, Engineering and Science.
2018 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Background- Osteoarthritis (OA) is a common, chronic disorder with a complex etiology including genetic and environmental factors. Metabolic triggered inflammation induced by obesity contributes to the inflammatory process and higher levels of pro-inflammatory cytokines and adipokines, which may play a role in OA pathophysiology. Obesity- related metabolic factors such as adipokines, contribute to OA development by inducing pro-inflammatory cytokines and degradative enzymes, leading to cartilage matrix damage and subchrondal bone remodeling. Aim- The aim of this study was to examine the association between visceral fat, obesity and a biomarker for inflammation (C-reactive protein, CRP) in a group of people experiencing symptomatic knee pain. Methods- Adults (n=89) of varying ages between 30-63 years, experiencing symptomatic knee pain or diagnosed knee OA were tested once. Levels of CRP were analyzed with the sandwich ELISA method (Enzyme-Linked ImmunoSorbent Assay). Visceral Fat Area (VFA) and Body Mass Index (BMI) were measured through bioelectrical impedance analysis (BIA) using InBody 770. Waist-to-hip ratio (WHR) was measured using measuring tape. Differences between groups and within groups were analyzed using Wilcoxon and Mann-Whitney U test. Spearmans correlation was used to calculate the strength of the correlation between the variables CRP and VFA, BMI and WHR. Partial correlation was used when controlling for gender. Results- The associations between CRP and VFA (r= 0.469, r2= 0.22), CRP and BMI (r= 0.446, r2= 0.20) and CRP and WHR (r= 0.307, r2= 0.09) were considered as medium correlations. Patients with VFA above 137.35 cm2 showed a significant higher CRP (p=0.002) than patients with VFA 137.35 cm2 or below. Patients with WHR 0.96 or above showed a significant higher CRP (p=0.030) than patients with WHR <0.96. Conclusion- The result of this study suggests that an increasing VFA, BMI and WHR provide a higher CRP level. 

Abstract [sv]

Bakgrund- Artros är en vanlig, kronisk sjukdom med komplex etiologi och påverkas av både genetiska och miljömässiga faktorer. Metabolt triggad inflammation inducerad av fetma, bidrar till aktivering av inflammationsprocessen och högre nivåer av pro-inflammatoriska cytokiner och adipokiner, vilket kan spela en central roll för patofysiologin i utvecklingen av artros. Fetma-relaterade metaboliska faktorer, såsom adipokiner, bidrar till progression av artros genom produktion av pro-inflammatoriska cytokiner samt degraderande enzymer, vilket leder till nedbrytning av ledbrosk och subkrondal benreformering.Syfte- Syftet med studien var att undersöka sambandet mellan visceralt fett, fetma och en biomarkör för inflammation (C-reaktivt protein, CRP) hos en grupp personer som upplever symtomatisk knäartros. Metod- Vuxna (n = 89) i varierande åldrar mellan 30-63 år som upplevde symtomatisk knäartros eller var diagnostiserade med knäartros testades en gång. Nivåerna av CRP analyserades med sandwich-ELISA (Enzyme-Linked ImmunoSorbent Assay). Visceral fett area (VFA) och Body Mass Index (BMI) mättes genom bioelektrisk impedansanalys (BIA) genom användning av InBody 770. Midje-höftkvot (WHR) mättes med måttband. Skillnader mellan grupper och inom grupper analyserades med Wilcoxon och Mann-Whitney U-test. Spearmans korrelation användes för att beräkna styrkan i korrelationen mellan variablerna CRP och VFA, BMI och WHR. Partiell korrelation användes vid kontroll för kön. Resultat- Korrelationerna mellan CRP och VFA (r = 0,449, r2 = 0,22), CRP och BMI (r = 0,466, r2 = 0,20) och CRP och WHR (r = 0,307, r2 = 0,09) ansågs vara medium starka korrelationer. Patienter med VFA över 137,35 cm2 uppvisade ett signifikant högre CRP (p = 0,002) än patienter med VFA 137,35 cm2 eller lägre. Patienter med WHR 0.96 eller högre uppvisade ett signifikant högre CRP (p = 0,030) än patienter med WHR <0.96. Slutsats- Resultatet av studien tyder på att ökande nivåer av visceralt fett i form av; VFA, BMI och WHR bidrar till en högre koncentration av CRP i blodet. 

Place, publisher, year, edition, pages
2018. , p. 31
Series
Frida Norman
National Category
Natural Sciences Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-36837OAI: oai:DiVA.org:hh-36837DiVA, id: diva2:1210464
Educational program
Exercise Biomedicine, 180 credits
Supervisors
Examiners
Available from: 2018-06-12 Created: 2018-05-28 Last updated: 2018-06-12Bibliographically approved

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