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Analysis of polymorphisms in the mediator complex subunit 13-like (Med13L) gene in the context of immune function and development of experimental arthritis
University of Copenhagen, Copenhagen, Denmark & Nordic Bioscience A/S, Copenhagen, Denmark.
University of Copenhagen, Copenhagen, Denmark & Novartis International AG, Copenhagen, Denmark.
Halmstad University, School of Business, Engineering and Science, The Rydberg Laboratory for Applied Sciences (RLAS). University of Copenhagen, Copenhagen, Denmark.ORCID iD: 0000-0003-4360-7710
2018 (English)In: Archivum Immunologiae et Therapiae Experimentalis, ISSN 0004-069X, E-ISSN 1661-4917Article in journal (Refereed) Epub ahead of print
Abstract [en]

The Mediator complex subunit 13-like (MED13L) protein is part of the multi-protein mediator complex and plays an important role in gene transcription. Polymorphisms in the MED13L gene have been linked to congenital heart anomalies and intellectual disabilities. Despite recent evidence of indirect links of MED13L to cytokine release and inflammation, impact of genetic variations in MED13L on immune cells remains unexplored. The B10.RIII and RIIIS/J mouse strains vary in susceptibility to induced experimental autoimmune disease models. From sequencing data of the two mouse strains, we identified six polymorphisms in the coding regions of Med13l. By using congenic mice, we studied the effect of these polymorphisms on immune cell development and function along with susceptibility to collagen-induced arthritis, an animal model for Rheumatoid Arthritis (RA). Combining in vivo disease data, in vitro functional data, and computational analysis of the reported non-synonymous polymorphisms, we report that genetic polymorphisms in Med13l do not affect the immune phenotype in these mice and are predicted to be non-disease associated. © The Author(s) 2018

Place, publisher, year, edition, pages
Basel: Springer, 2018.
Keywords [en]
MED13L, THRAP2, mediator complex, Collagen-induced arthritis, Rheumatoid Arthritis, congenic mice
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:hh:diva-36795DOI: 10.1007/s00005-018-0516-8PubMedID: 29951696OAI: oai:DiVA.org:hh-36795DiVA, id: diva2:1209094
Note

This work was supported by The Danish Rheumatism Association, The AP Møller Research grant for Medical Science, and The Oticon foundation.

Available from: 2018-05-21 Created: 2018-05-21 Last updated: 2018-07-04

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