Tight coupling between the performance of vehicleto-vehicle (V2V) communications and the performance of Cooperative Intelligent Transportation Systems (C-ITS) safety applications is addressed. A Cyber-Physical System (CPS) analytical framework is developed that links the characteristics of V2V communications (such as packet loss probability and packet transmission delay) with the physical mobility characteristics of the vehicular system (such as safe inter-vehicular distance). The study is applied to the Day 1 C-ITS application, Emergency Electronic Brake Lights (EEBL), enabled by ETSI ITS-G5 and IEEE 802.11p standards. © 2018 IEEE