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A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation
University of Copenhagen, Copenhagen, Denmark & Novo Nordisk A/S, Bagsværd, Denmark.
Yale University School of Medicine, New Haven, CT, USA.
University of Copenhagen, Copenhagen, Denmark & Novozymes A/S, Bagsværd, Denmark.
University of Copenhagen, Copenhagen, Denmark & Xelia Pharmaceuticals A/S, Copenhagen, Denmark.
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2018 (English)In: Journal of Neuroimmune Pharmacology, ISSN 1557-1890, E-ISSN 1557-1904Article in journal (Refereed) Epub ahead of print
Abstract [en]

Multiple sclerosis is a neuroinflammatory degenerative disease, caused by activated immune cells infiltrating the CNS. The disease etiology involves both genetic and environmental factors. The mouse genetic locus, Eae27, linked to disease development in the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis, was studied in order to identify contributing disease susceptibility factors and potential drug targets for multiple sclerosis. Studies of an Eae27 congenic mouse strain, revealed that genetic variation within Eae27 influences EAE development. The Abl2 gene, encoding the non-receptor tyrosine kinase Arg, is located in the 4,1 megabase pair long Eae27 region. The Arg protein plays an important role in cellular regulation and is, in addition, involved in signaling through the B- and T-cell receptors, important for the autoimmune response. The presence of a single nucleotide polymorphism causing an amino acid change in a near actin-interacting domain of Arg, in addition to altered lymphocyte activation in the congenic mice upon immunization with myelin antigen, makes Abl2/Arg a candidate gene for EAE. Here we demonstrate that the non-synonymous SNP does not change Arg’s binding affinity for F-actin but suggest a role for Abl kinases in CNS inflammation pathogenesis by showing that pharmacological inhibition of Abl kinases ameliorates EAE, but not experimental arthritis. © 2018 The Author(s)

Place, publisher, year, edition, pages
New York, NY: Springer-Verlag New York, 2018.
Keyword [en]
Abl kinase, Arg, Eae27, Experimental autoimmune encephalomyelitis, Imatinib
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:hh:diva-36440DOI: 10.1007/s11481-018-9783-8PubMedID: 29550892Scopus ID: 2-s2.0-85044043378OAI: oai:DiVA.org:hh-36440DiVA, id: diva2:1190915
Note

Funding: Novo Nordisk, Denmark; SHARE (Synergy in human and animal research) University of Copenhagen; The Warwara Larsen Foundation, The Carlsberg Foundation; The Karen A. Tolstrup Foundation; The A.P. Møller Foundation.

Available from: 2018-03-16 Created: 2018-03-16 Last updated: 2018-04-17

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