Despite the existing regulation efforts and measures, vehicles with dangerous goods still pose significant risks on public safety, especially in road tunnels. Solutions based on cooperative intelligent transportation system (C-ITS) are promising measures, however, they have received limited attention. We propose C-ITS applications that coordinate dangerous goods vehicles to minimize the risk by maintaining safe distances between them in road tunnels. Different mechanisms, including global centralized coordination, global distributed coordination, and local coordination, are proposed and investigated. A preliminary simulation is performed and demonstrates their effectiveness. © 2015 IEEE.