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Absent "Window of Opportunity" in smokers with short disease duration. Data from BARFOT, a multicenter study of early rheumatoid arthritis
R and D Center, Spenshult Rheumatology Hospital, Oskarström, Sweden.
R and D Center, Spenshult Rheumatology Hospital, Oskarström, Sweden.ORCID iD: 0000-0002-6294-538X
2011 (English)In: Journal of Rheumatology, ISSN 0315-162X, E-ISSN 1499-2752, Vol. 38, no 10, 2160-2168 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To study the effect of disease duration and smoking on outcome in early rheumatoid arthritis (RA).

METHODS: Between 1996 and 2004, 1587 patients were included in the BARFOT early RA (disease duration ≤ 1 year) study in Sweden. European League Against Rheumatism (EULAR) response, Health Assessment Questionnaire (HAQ), rheumatoid factor (RF), and antibodies to cyclic citrullinated peptide (anti-CCP) were recorded at study start and at 3, 6, and 12 months.

RESULTS: In total, 180 RA patients (11%) had disease duration ≤ 12 weeks. These patients achieved good EULAR response significantly more often at 3 and 12 months than patients with a longer disease duration despite having more aggressive disease [EULAR good response was achieved by 35% and 35% at 3 and 12 months, respectively, among the patients with disease duration ≤ 12 weeks, by 35% and 41% of patients with disease duration of 13-24 weeks, and by 28% and 33% of patients with disease duration of 25-52 weeks (p = 0.02 for 3 months; p = 0.02 for 12 months)]. There was a significant correlation between improvement in Disease Activity Score-28 (DAS28), its individual variables, and Health Assessment Questionnaire (HAQ) and disease duration up to 12 months after study start. For smokers, no such trend was seen.

CONCLUSION: Up to 12 months after inclusion in the study, there was a significant correlation between improvement in DAS28, its individual components, and HAQ and disease duration, with patients who had a shorter disease duration improving most. Smokers had poorer EULAR response and showed no improvement with regard to disease duration. The Journal of Rheumatology Copyright © 2011. All rights reserved.

Place, publisher, year, edition, pages
Toronto: Journal of Rheumatology Publishing Co. Ltd. , 2011. Vol. 38, no 10, 2160-2168 p.
Keyword [en]
Early rheumatoid arthritis, Epidemiology, Smoking
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:hh:diva-32304DOI: 10.3899/jrheum.100991ISI: 000296545400013PubMedID: 21807778Scopus ID: 2-s2.0-80053554610OAI: oai:DiVA.org:hh-32304DiVA: diva2:1039955
Available from: 2016-10-25 Created: 2016-10-25 Last updated: 2017-11-29Bibliographically approved

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