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Transient isotachophoresis for sensitivity enhancement in capillary electrophoresis-mass spectrometry for peptide analysis
DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, Mölndal, Sweden.
DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, Mölndal, Sweden.
2000 (engelsk)Inngår i: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 21, nr 14, s. 2859-2865Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Transient isotachophoresic (ITP) focusing was used for the on-line analysis of peptides by capillary zone electrophoresis-mass spectrometry (CZE-MS), allowing injection volumes of up to 0.9 microL. A sheath liquid electrospray interface was used with a single quadrupole mass analyzer. First, the technique was applied to the qualitative analysis of a tryptic digest of cytochrome c, resulting in low-background, high-quality spectra. Second, the linear range was investigated by selected ion monitoring (SIM) for a peptidomimetic direct thrombin inhibitor melagatran (Mr 429.5) and two endogenous peptides, substance P (Mr 1348) and calcitonin gene-related peptide (alpha-CGRP; Mr 3806).

sted, utgiver, år, opplag, sider
Weinheim: Wiley-VCH Verlagsgesellschaft, 2000. Vol. 21, nr 14, s. 2859-2865
Emneord [en]
Isotachophoresis, Capillary electrophoresis, Mass spectrometry, Peptides
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Identifikatorer
URN: urn:nbn:se:hh:diva-24122DOI: 10.1002/1522-2683(20000801)21:14<2859::AID-ELPS2859>3.0.CO;2-FISI: 000089275400015PubMedID: 11001295Scopus ID: 2-s2.0-0033821046OAI: oai:DiVA.org:hh-24122DiVA, id: diva2:679535
Tilgjengelig fra: 2013-12-16 Laget: 2013-12-09 Sist oppdatert: 2018-03-22bibliografisk kontrollert

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