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Abnormal Function of C-Fibers in Patients with Diabetic Neuropathy
Faculty of Medicine, University of Oslo.
Department of Physiology and Experimental Pathophysiology, University of Erlangen/Nürnberg.
Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden.
Department of Anesthesiology Mannheim, University Heidelberg, Mannheim, Germany,.
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2006 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 26, no 44, p. 11287-11294Article in journal (Refereed) Published
Abstract [en]

The mechanisms underlying the development of painful and nonpainful neuropathy associated with diabetes mellitus are unclear. We have obtained microneurographic recordings from unmyelinated fibers in eight patients with diabetes mellitus, five with painful neuropathy, and three with neuropathy without pain. All eight patients had large-fiber neuropathy, and seven patients had pathological thermal thresholds in their feet, indicating the involvement of small-caliber nerve fibers. A total of 163 C-fibers were recorded at knee level from the common peroneal nerve in the patients (36–67 years old), and these were compared with 77 C-fibers from healthy controls (41–64 years old). The ratio of mechano-responsive to mechano-insensitive nociceptors was ~2:1 in the healthy controls, whereas in the patients, it was 1:2. In patients, a fairly large percentage of characterized fibers (12.5% in nonpainful and 18.9% in painful neuropathy) resembled mechano-responsive nociceptors that had lost their mechanical and heat responsiveness. Such fibers were rarely encountered in age-matched controls (3.2%). Afferent fibers with spontaneous activity or mechanical sensitization were found in both patient groups. We conclude that small-fiber neuropathy in diabetes affects receptive properties of nociceptors that leads to an impairment of mechano-responsive nociceptors. Copyright © 2006 Society for Neuroscience

Place, publisher, year, edition, pages
Washington DC, USA: The Society for Neuroscience , 2006. Vol. 26, no 44, p. 11287-11294
Keywords [en]
Neuropathy, Diabetes, Pain, C-fibers, Microneurography, Degeneration
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-1093DOI: 10.1523/JNEUROSCI.2659-06.2006ISI: 000241727500007PubMedID: 17079656Scopus ID: 2-s2.0-33750935695Local ID: 2082/1470OAI: oai:DiVA.org:hh-1093DiVA, id: diva2:238311
Available from: 2008-01-29 Created: 2008-01-29 Last updated: 2018-03-23Bibliographically approved

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Hilliges, Marita

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