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Abnormal Function of C-Fibers in Patients with Diabetic Neuropathy
Faculty of Medicine, University of Oslo.
Department of Physiology and Experimental Pathophysiology, University of Erlangen/Nürnberg.
Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden.
Department of Anesthesiology Mannheim, University Heidelberg, Mannheim, Germany,.
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2006 (Engelska)Ingår i: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 26, nr 44, s. 11287-11294Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The mechanisms underlying the development of painful and nonpainful neuropathy associated with diabetes mellitus are unclear. We have obtained microneurographic recordings from unmyelinated fibers in eight patients with diabetes mellitus, five with painful neuropathy, and three with neuropathy without pain. All eight patients had large-fiber neuropathy, and seven patients had pathological thermal thresholds in their feet, indicating the involvement of small-caliber nerve fibers. A total of 163 C-fibers were recorded at knee level from the common peroneal nerve in the patients (36–67 years old), and these were compared with 77 C-fibers from healthy controls (41–64 years old). The ratio of mechano-responsive to mechano-insensitive nociceptors was ~2:1 in the healthy controls, whereas in the patients, it was 1:2. In patients, a fairly large percentage of characterized fibers (12.5% in nonpainful and 18.9% in painful neuropathy) resembled mechano-responsive nociceptors that had lost their mechanical and heat responsiveness. Such fibers were rarely encountered in age-matched controls (3.2%). Afferent fibers with spontaneous activity or mechanical sensitization were found in both patient groups. We conclude that small-fiber neuropathy in diabetes affects receptive properties of nociceptors that leads to an impairment of mechano-responsive nociceptors. Copyright © 2006 Society for Neuroscience

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Washington DC, USA: The Society for Neuroscience , 2006. Vol. 26, nr 44, s. 11287-11294
Nyckelord [en]
Neuropathy, Diabetes, Pain, C-fibers, Microneurography, Degeneration
Nationell ämneskategori
Neurologi
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URN: urn:nbn:se:hh:diva-1093DOI: 10.1523/JNEUROSCI.2659-06.2006ISI: 000241727500007PubMedID: 17079656Scopus ID: 2-s2.0-33750935695Lokalt ID: 2082/1470OAI: oai:DiVA.org:hh-1093DiVA, id: diva2:238311
Tillgänglig från: 2008-01-29 Skapad: 2008-01-29 Senast uppdaterad: 2020-05-11Bibliografiskt granskad

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