Determinant frameworks are used in implementation science to describe and categorize influences (i.e. determinants) on the implementation of evidence-based practices. Determinants are typically divided into barriers (or hindrances) and facilitators (or enablers or drivers) of implementation. Knowledge about implementation determinants is important to develop and select appropriate strategies to overcome barriers and harness facilitators to support the implementation of evidence-based interventions, programmes, services and other practices. This chapter looks at the origins, content and use of six determinant frameworks. © 2024 selection and editorial matter, Per Nilsen; individual chapters, the contributors.