hh.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Baseline levels of circulating galectin-1 associated with radiographic hand but not radiographic knee osteoarthritis at a two-year follow-up
Halmstad University, School of Business, Innovation and Sustainability. Spenshult Research and Development Center, Halmstad, Sweden; Lund University, Lund, Sweden.ORCID iD: 0000-0002-0217-5029
Helsingborg Hospital, Helsingborg, Sweden; Lund University, Lund, Sweden.ORCID iD: 0000-0002-9925-3838
Lund University, Lund, Sweden; Skåne University Hospital, Lund, Sweden.ORCID iD: 0000-0003-4717-1766
Spenshult Research and Development Center, Halmstad, Sweden; Lund University, Lund, Sweden; Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID iD: 0000-0002-6294-538X
Show others and affiliations
2024 (English)In: Osteoarthritis and Cartilage Open, E-ISSN 2665-9131, Vol. 6, no 2, article id 100455Article in journal (Refereed) In press
Abstract [en]

Objective: We tested the potential of circulating galectin-1, interleukin (IL)-1 beta, IL-6, and tumour necrosis factor alpha (TNF alpha) levels at baseline in individuals with knee pain as biomarkers for development of radiographic knee and/or hand osteoarthritis (OA). Design: This study comprised 212 individuals with knee pain from the Halland osteoarthritis cohort (HALLOA). Clinical characteristics and serum/plasma levels of galectin-1, IL-1 beta, IL-6, and TNF alpha were measured at baseline, and knee and hand radiographs were obtained at a two-year follow-up. The predictive value of circulating inflammatory markers and clinical variables at baseline was assessed using multinominal logistic regression for those who developed radiographic OA in knees only (n ​= ​25), in hands only (n ​= ​40), and in both knees and hands (n ​= ​43); the group who did not develop OA (n ​= ​104) was used as reference. Correlations were assessed using Spearman's correlation coefficients. Results: As expected, age was identified as a risk factor for having radiographic knee and/or hand OA at the two-year follow-up. Baseline circulating galectin-1 levels did not associate with developing radiographic knee OA but associated with developing radiographic hand OA (odds ratio (OR) for a 20% increased risk: 1.14, 95% confidence interval (CI) 1.01–1.29) and both radiographic knee and hand OA (OR for a 20% increased risk: 1.18, 95% CI 1.05–1.30). However, baseline IL-1 beta, IL-6, and TNF alpha did not associate with developing radiographic knee and/or hand OA. Conclusion: Non-age adjusted circulating galectin-1 is superior to IL-6, IL-1 beta, and TNF alpha in predicting radiographic hand but not knee OA. © 2024 The Author(s)

Place, publisher, year, edition, pages
Oxford: Elsevier, 2024. Vol. 6, no 2, article id 100455
Keywords [en]
Galectin-1, Hand, Knee, Osteoarthritis
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:hh:diva-52956DOI: 10.1016/j.ocarto.2024.100455PubMedID: 38469554Scopus ID: 2-s2.0-85186373840OAI: oai:DiVA.org:hh-52956DiVA, id: diva2:1846549
Funder
Swedish Rheumatism Association, R-531621; R-635431, R-939824; R-967899The Crafoord FoundationRegion SkåneLund UniversitySwedish Research Council, 2022-01011 (PAJ)Available from: 2024-03-22 Created: 2024-03-22 Last updated: 2024-03-22Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Andersson, Maria L.E.Bergman, Stefan

Search in DiVA

By author/editor
Andersson, Maria L.E.Zimmerman, M.Brogren, E.Bergman, Stefan
By organisation
School of Business, Innovation and Sustainability
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 7 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf