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Effects on serum protein levels from one bout of high intensity interval training in individuals with axial spondyloarthritis and controls
Högskolan i Halmstad, Akademin för företagande, innovation och hållbarhet. (Exercise Biomedicine)ORCID-id: 0000-0003-4360-7710
Högskolan i Halmstad, Akademin för företagande, innovation och hållbarhet.ORCID-id: 0000-0002-9337-5113
Ängelholm hospital, Ängelholm, Sweden.ORCID-id: 0009-0001-3870-1027
Lund University, Skåne University Hospital, Lund, Sweden.ORCID-id: 0000-0002-5706-203X
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(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Abstract [en]

Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on disease activity and the level of inflammation in axSpA has been less studied. With the aim of investigating how levels of inflammatory cytokines, myokines, and protein markers for bone metabolism are acutely affected by one bout of HIIT, we studied serum from individuals with axSpA and healthy controls (HC).

Methods: Ten participants with axSpA and 11 age- and sex-matched HC performed a single HIIT bout on a cycle ergometer: 4x4 minutes intervals with three minutes active rest in between. Blood samples were taken before and one hour after the HIIT bout. Serum proteins (IL-6, IL-17, IL-18, TNFa, CXCL-10, VEGF-A, BDNF, DKK-1, osteoprotegerin, osteocalcin, osteopontin, BMP-7, CRP) were analyzed with a Luminex system or ELISA. Descriptive data are presented as mean with standard deviation. A two-way ANOVA was used for comparisons.

Results: A main effect from baseline to one hour post HIIT showed that both groups had a significant increase in serum levels (pg/ml) of IL-6: axSpA 2.2 (3.0) to 3.2 (1.8) and HC 0.4 (0.4) to 1.9 (2.0), p=0.03. VEGF-A (pg/ml) was significantly lower in the axSpA group: 159 (138) vs. HC 326 (184), p=0.03, but was not affected by the HIIT bout. BMP-7 (ng/ml) increased in both groups after the HIIT: axSpA 61.6 (13.1) to 75.2 (20.0) and HC 64.6 (20.8 to 75.0 (17.8), p<0.001. For the other proteins analyzed, there were no significant differences in serum concentrations between individuals with axSpA and HC, or within the two groups before and after one bout of HIIT.

Conclusions: One acute bout of HIIT significantly increases the serum concentrations of IL-6 and BMP-7 after 1 hour in both individuals with axSpA and HC.

© Research Square 2024

Nyckelord [en]
Axial spondyloarthritis, high-intensity interval training, exercise rehabilitation, IL-6, BMP-7, CRP
Nationell ämneskategori
Reumatologi och inflammation
Forskningsämne
Hälsoinnovation, M4HP
Identifikatorer
URN: urn:nbn:se:hh:diva-52357DOI: 10.21203/rs.3.rs-3564226/v1OAI: oai:DiVA.org:hh-52357DiVA, id: diva2:1824366
Forskningsfinansiär
Reumatikerförbundet
Anmärkning

Published at Research Square ISSN 2693-5015

Tillgänglig från: 2024-01-05 Skapad: 2024-01-05 Senast uppdaterad: 2024-07-05Bibliografiskt granskad

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Andersson, ÅsaOlsson, M. CharlotteTorell, AnnaHaglund, Emma

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Andersson, ÅsaOlsson, M. CharlotteTorell, AnnaMogard, ElisabethHaglund, Emma
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Akademin för företagande, innovation och hållbarhet
Reumatologi och inflammation

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