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Reducing Sedentary Time and Whole-Body Insulin Sensitivity in Metabolic Syndrome: A 6-Month Randomized Controlled Trial
University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.
University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.
University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.
The UKK Institute for Health Promotion Research, Tampere, Finland.
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2023 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 55, no 3, p. 342-353Article in journal (Refereed) Published
Abstract [en]

Purpose: This study aimed to investigate whether a reduction in daily sedentary behavior (SB) improves insulin sensitivity in adults with metabolic syndrome in 6 months, without adding intentional exercise training.

Methods: Sixty-four sedentary inactive middle-age adults with overweight and metabolic syndrome (mean (SD) age, 58 (7) yr; mean (SD) body mass index, 31.6 (4.3) kg.m(-2); 27 men) were randomized into intervention and control groups. The 6-month individualized behavioral intervention supported by an interactive accelerometer and a mobile application aimed at reducing daily SB by 1 h compared with baseline. Insulin sensitivity by hyperinsulinemic euglycemic clamp, body composition by air displacement plethysmography, and fasting blood samples were analyzed before and after the intervention. SB and physical activity were measured with hip-worn accelerometers throughout the intervention.

Results: SB decreased by 40 (95% confidence interval, 17-65) min.d(-1), and moderate-to-vigorous physical activity increased by 20 (95% confidence interval, 11-28) min.d(-1) on average in the intervention group with no significant changes in these outcomes in the control group. After 6 months, fasting plasma insulin decreased (similar to 1 mU.L-1) in the intervention group compared with the control group (time-group, P = 0.0081), but insulin sensitivity did not change in either group. The changes in body mass or adiposity did not differ between groups. Among all participants, the changes in SB and body mass correlated inversely with the change in insulin sensitivity (r = -0.31, -0.44; P = 0.025, 0.0005, respectively).

Conclusions: An intervention aimed at reducing daily SB resulted in slightly decreased fasting insulin, but had no effects on insulin sensitivity or body adiposity. However, as the change in insulin sensitivity associated with the changes in SB and body mass, multifaceted interventions targeting to weight loss are likely to be beneficial in improving whole-body insulin sensitivity. © Lippincott Williams & Wilkins.

Place, publisher, year, edition, pages
Philadelphia, PA: Lippincott Williams & Wilkins, 2023. Vol. 55, no 3, p. 342-353
Keywords [en]
Sedentary Behavior, Physical Activity, Metabolic Syndrome, Insulin Resistance, Overweight, Accelerometry
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:hh:diva-52188DOI: 10.1249/MSS.0000000000003054ISI: 000931685900002PubMedID: 36251378Scopus ID: 2-s2.0-85148113565&OAI: oai:DiVA.org:hh-52188DiVA, id: diva2:1817515
Note

The study was financially supported by the Finnish Cultural Foundation, the Juho Vainio Foundation, Academy of Finland, the Hospital District of Southwest Finland, the Yrjö Jahnsson Foundation, the Turku University Foundation, Diabetestutkimussäätiö (the Finnish Diabetes Research Foundation), and TYKS-foundation.

Available from: 2023-12-06 Created: 2023-12-06 Last updated: 2023-12-06Bibliographically approved

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