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Associations between chronic widespread pain, pressure pain thresholds, leptin, and metabolic factors in individuals with knee pain
Halmstad University, School of Business, Innovation and Sustainability. Spenshult Research and Development Centre, Halmstad, Sweden; Lund University, Lund, Sweden.ORCID iD: 0000-0002-0217-5029
Spenshult Research and Development Centre, Halmstad, Sweden.
Halmstad University, School of Health and Welfare. Spenshult Research and Development Centre, Halmstad, Sweden.ORCID iD: 0000-0002-8895-1227
Spenshult Research and Development Centre, Halmstad, Sweden; University of Gothenburg, Gothenburg, Sweden.ORCID iD: 0000-0002-6294-538X
2023 (English)In: BMC Musculoskeletal Disorders, E-ISSN 1471-2474, Vol. 24, no 1, article id 639Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The aim was to study associations between chronic widespread pain, widespread pain sensitivity, leptin, and metabolic factors in individuals with knee pain. A secondary aim was to study these associations in a subgroup of individuals with normal BMI.

METHOD: This cross-sectional study included 265 individuals. The participants were categorised into three different pain groups: Chronic widespread pain (CWP), chronic regional pain (ChRP), or no chronic pain (NCP). The pressure pain thresholds (PPTs) were assessed using computerised pressure algometry. Low PPTs were defined as having PPTs in the lowest third of all tender points. Leptin and metabolic factors such as BMI, visceral fat area (VFA), lipids, and glucose were also assessed.

RESULT: Sixteen per cent reported CWP, 15% had low PPTs, and 4% fulfilled both criteria. Those who fulfilled the criteria for CWP were more often women, more obese, and had increased leptin levels. In logistic regression, adjusted for age and gender, leptin was associated with fulfilling criteria for CWP, OR 1.015 (95% CI 1.004-1.027, p = 0.008). In logistic regression, adjusted for age and gender, leptin was associated with low PPTs, OR 1.016 (95% CI 1.004-1.029, p = 0.012). Leptin was also associated with fulfilling both criteria, adjusted for age, sex, and visceral fat area (VFA), OR 1.030 (95% CI 1.001-1.060), p = 0.040.

CONCLUSION: Leptin was associated with fulfilling the combined criteria for chronic widespread pain and low PPTs, even after adjusting for the visceral fat area (VFA). Longitudinal studies are needed to study the causal relationships between leptin and the development of widespread pain.

Place, publisher, year, edition, pages
London: BioMed Central (BMC), 2023. Vol. 24, no 1, article id 639
Keywords [en]
Chronic widespread pain, Leptin, Metabolic factors, Pressure pain thresholds
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:hh:diva-51567DOI: 10.1186/s12891-023-06773-4ISI: 001044916800001PubMedID: 37559026Scopus ID: 2-s2.0-85167532783OAI: oai:DiVA.org:hh-51567DiVA, id: diva2:1793937
Funder
The Crafoord FoundationSwedish Rheumatism Association
Note

Funding text: Open access funding provided by Lund University. The study was funded by the Swedish Rheumatism Association, grant numbers R-531621, R-635431, R-939824, and R-967899; targeted investment from the Swedish Rheumatism Association – Osteoarthritis from 2014 to 2019, and the Crafoord Foundation. The funders have not influenced the study design, collection, analysis, or interpretation of data, nor the writing of the manuscript or the decision to submit the manuscript for publication.

Available from: 2023-09-04 Created: 2023-09-04 Last updated: 2024-01-17Bibliographically approved

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Andersson, Maria L.E.Sylwander, CharlotteBergman, Stefan

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