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The effects of a 6-month intervention aimed to reduce sedentary time on skeletal muscle insulin sensitivity: a randomized controlled trial
Turku PET Centre, Åbo, Finland; University of Turku, Turku, Finland; Åbo Akademi University, Åbo, Finland; Turku University Hospital, Turku, Finland.ORCID iD: 0000-0003-4477-8175
Turku PET Centre, Åbo, Finland; University of Turku, Turku, Finland; Åbo Akademi University, Åbo, Finland; Turku University Hospital, Turku, Finland.ORCID iD: 0000-0002-4962-9550
Turku PET Centre, Åbo, Finland; University of Turku, Turku, Finland; Åbo Akademi University, Åbo, Finland; Turku University Hospital, Turku, Finland.ORCID iD: 0000-0003-2770-5417
The UKK Institute for Health Promotion Research, Tampere, Finland.ORCID iD: 0000-0001-7537-2501
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2023 (English)In: American Journal of Physiology. Endocrinology and Metabolism, ISSN 0193-1849, E-ISSN 1522-1555, Vol. 325, no 2, p. E152-E162Article in journal (Refereed) Published
Abstract [en]

Sedentary behavior (SB) and physical inactivity associate with impaired insulin sensitivity. We investigated whether an intervention aimed at a 1-h reduction in daily SB during 6 mo would improve insulin sensitivity in the weight-bearing thigh muscles. Forty-four sedentary inactive adults [mean age 58 (SD 7) yr; 43% men] with metabolic syndrome were randomized into intervention and control groups. The individualized behavioral intervention was supported by an interactive accelerometer and a mobile application. SB, measured with hip-worn accelerometers in 6-s intervals throughout the 6-mo intervention, decreased by 51 (95% CI 22-80) min/day and physical activity (PA) increased by 37 (95% CI 18-55) min/day in the intervention group with nonsignificant changes in these outcomes in the control group. Insulin sensitivity in the whole body and in the quadriceps femoris and hamstring muscles, measured with hyperinsulinemic-euglycemic clamp combined with [18F]fluoro-deoxy-glucose PET, did not significantly change during the intervention in either group. However, the changes in hamstring and whole body insulin sensitivity correlated inversely with the change in SB and positively with the changes in moderate-to-vigorous PA and daily steps. In conclusion, these results suggest that the more the participants were able to reduce their SB, the more their individual insulin sensitivity increased in the whole body and in the hamstring muscles but not in quadriceps femoris. However, according to our primary randomized controlled trial results, this kind of behavioral interventions targeted to reduce sedentariness may not be effective in increasing skeletal muscle and whole body insulin sensitivity in people with metabolic syndrome at the population level.

NEW & NOTEWORTHY Aiming to reduce daily SB by 1 h/day had no impact on skeletal muscle insulin sensitivity in the weight-bearing thigh muscles. However, successfully reducing SB may increase insulin sensitivity in the postural hamstring muscles. This emphasizes the importance of both reducing SB and increasing moderate-to-vigorous physical activity to improve insulin sensitivity in functionally different muscles of the body and thus induce a more comprehensive change in insulin sensitivity in the whole body.

Place, publisher, year, edition, pages
Rockville, MD: American Physiological Society, 2023. Vol. 325, no 2, p. E152-E162
Keywords [en]
insulin sensitivity, metabolic syndrome, physical activity, sedentary behavior, skeletal muscle
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:hh:diva-51385DOI: 10.1152/ajpendo.00018.2023ISI: 001034325400001PubMedID: 37378623Scopus ID: 2-s2.0-85165518559OAI: oai:DiVA.org:hh-51385DiVA, id: diva2:1787882
Funder
Academy of Finland
Note

FUNDING: The study was financially supported by the Academy of Finland, the Finnish Cultural Foundation, the Juho Vainio Foundation, the Hospital District of Southwest Finland, the Yrjö Jahnsson Foundation, the Turku University Foundation, Diabetestutkimussäätiö (the Finnish Diabetes Research Foundation), and Turku University Hospital (TYKS) foundation.

Available from: 2023-08-15 Created: 2023-08-15 Last updated: 2023-10-05Bibliographically approved

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Heinonen, Ilkka H. A.

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Sjöros, TanjaLaine, SaaraGarthwaite, TaruVähä-Ypyä, HenriLaitinen, KirsiKalliokoski, Kari K.Sievänen, HarriHeinonen, Ilkka H. A.
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