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Effects of reduced sedentary time on cardiometabolic health in adults with metabolic syndrome: A three-month randomized controlled trial
University Of Turku, Turku, Finland.
University Of Turku, Turku, Finland.
University Of Turku, Turku, Finland.
Ukk Institute For Health Promotion Research, Tampere, Finland.
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2022 (English)In: Journal of Science and Medicine in Sport, ISSN 1440-2440, E-ISSN 1878-1861, Vol. 25, no 7, p. 579-585Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate if reducing sedentary behavior improves cardiometabolic biomarkers in adults with metabolic syndrome. Design: Randomized controlled trial. Methods: Sixty-four sedentary middle-aged adults with metabolic syndrome were randomized into intervention (INT; n = 33) and control (CON; n = 31) groups. INT was guided to limit sedentary behavior by 1 h/day through increased standing and light-intensity physical activity. CON was instructed to maintain usual habits. Sedentary behavior, breaks in sedentary behavior, standing, and physical activity were measured with hip-worn accelerometers for three months. Fasting blood sampling and measurements of anthropometrics, body composition, and blood pressure were performed at baseline and at three months. Linear mixed models were used for statistical analyses. Results: INT reduced sedentary behavior by 50 (95% CI: 24, 73) min/day by increasing light-intensity and moderate-to-vigorous physical activity (19 [8, 30] and 24 [14, 34] min/day, respectively). Standing increased also, but non-significantly (6 [−11, 23] min/day). CON maintained baseline activity levels. Significant intervention effects favoring INT occurred in fasting insulin (INT: 83.4 [68.7, 101.2] vs. CON: 102.0 [83.3, 125.0] pmol/l at three months), insulin resistance (HOMA-IR; 3.2 [2.6, 3.9] vs. 4.0 [3.2, 4.9]), HbA1c (37 [36, 38] vs. 38 [37, 39] mmol/mol), and liver enzyme alanine aminotransferase (28 [24, 33] vs. 33 [28, 38] U/l). Conclusions: Reducing sedentary behavior by 50 min/day and increasing light-intensity and moderate-to-vigorous activity showed benefits in several cardiometabolic biomarkers in adults with metabolic syndrome. Replacing some of the daily sedentary behavior with light-intensity and moderate-to-vigorous physical activity may help in cardiometabolic disease prevention in risk populations. © 2022 The Authors

Place, publisher, year, edition, pages
Chatswood: Elsevier Ltd , 2022. Vol. 25, no 7, p. 579-585
Keywords [en]
Cardiovascular risk factors, Metabolic syndrome, Physical activity, Sedentary behavior
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:hh:diva-48094DOI: 10.1016/j.jsams.2022.04.002ISI: 000827843500010PubMedID: 35487860Scopus ID: 2-s2.0-85129116076OAI: oai:DiVA.org:hh-48094DiVA, id: diva2:1723180
Note

Funding text: This work was supported by Academy of Finland, Finnish Cultural Foundation, Finnish Diabetes Research Foundation, Hospital District of Southwest Finland, and Juho Vainio Foundation.

Available from: 2023-01-02 Created: 2023-01-02 Last updated: 2023-01-02Bibliographically approved

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Heinonen, Ilkka

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