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Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden
Lund University, Lund, Sweden; Spenshult Research and Development Centre, Halmstad, Sweden.ORCID iD: 0000-0002-0217-5029
Halmstad University, School of Business, Innovation and Sustainability. Lund University, Lund, Sweden.ORCID iD: 0000-0002-1445-5247
Halmstad University, School of Health and Welfare. Karolinska Institute, Stockholm, Sweden.ORCID iD: 0000-0003-4260-7399
University of Southern Denmark, Odense, Denmark; University Hospital of Southern Denmark, Sonderborg, Denmark.ORCID iD: 0000-0002-8081-579X
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2022 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 12, no 7, article id e057086Article in journal (Refereed) Published
Abstract [en]

Purpose: The overall objective in this study is to investigate the early development of radiographic knee osteoarthritis (OA) and its association with hand or/and knee OA, metabolic diseases, biomarkers, chronic pain, physical function and daily physical activity types.

Participants: The Halland osteoarthritis (HALLOA) cohort is a longitudinal cohort study that includes individuals with knee pain in the southwest of Sweden. Enrolment took place from 2017 to 2019. The inclusion criteria were current knee pain, with no former known radiographic knee OA and no cruciate ligament rupture or rheumatological disorder. The participants were recruited: (1) when seeking care for knee pain in primary healthcare or (2) by advertisements in local newspapers. There are 306 individuals included in the study, mean age (SD) 51.7 (8.7) years and 69% are women. The baseline and follow-ups include clinical tests, radiographical examinations, blood samples, metabolic measures, pain pressure thresholds, tests of physical functions, daily physical activity types and patient-reported outcomes.

Findings to date: There were associations between metabolic factors and radiographic knee OA, even in those with normal body mass index at baseline. In addition, clinical hand OA was positively associated with fasting plasma glucose. We also found that modifiable factors as increased visceral fat and total body fat were associated with increased pain sensitivity among individuals with knee pain.

Future plans: By studying possible pathophysiological mechanisms of OA over time, we aim to provide new insights on OA progression, identify usable preventive measures helping the clinicians in the management of the disease and improve health for the patients. It is also important to study the development of chronic pain in OA, to get tools to identify individuals at risk and to be able to offer them treatment.

 © Author(s) (or their employer(s)) 2022. 

Place, publisher, year, edition, pages
London: BMJ Publishing Group Ltd, 2022. Vol. 12, no 7, article id e057086
Keywords [en]
Internal Medicine, Knee, Musculoskeletal disorders, Rheumatology
National Category
Rheumatology and Autoimmunity Health Sciences
Identifiers
URN: urn:nbn:se:hh:diva-48969DOI: 10.1136/bmjopen-2021-057086ISI: 000826598000010PubMedID: 35835523Scopus ID: 2-s2.0-85134137962OAI: oai:DiVA.org:hh-48969DiVA, id: diva2:1720641
Funder
Swedish Rheumatism Association, R-531621Swedish Rheumatism Association, R-635431Swedish Rheumatism Association, R-939824Swedish Rheumatism Association, R-967899The Crafoord Foundation
Note

Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Available from: 2022-12-20 Created: 2022-12-20 Last updated: 2023-08-28Bibliographically approved

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Haglund, EmmaAili, KatarinaBremander, AnnBergman, Stefan

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