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Associations between metabolic factors and radiographic knee osteoarthritis in early disease - a cross-sectional study of individuals with knee pain
Department of Clinical Sciences Lund, Lund, Sweden; Spenshult Research and Development Centre, Halmstad, Sweden.ORCID iD: 0000-0002-0217-5029
Halmstad University, School of Business, Innovation and Sustainability. Department of Clinical Sciences Lund, Lund, Sweden; Spenshult Research and Development Centre, Halmstad, Sweden.ORCID iD: 0000-0002-1445-5247
Halmstad University, School of Health and Welfare. Spenshult Research and Development Centre, Halmstad, Sweden; Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-4260-7399
Department of Clinical Sciences Lund, Lund, Sweden; Spenshult Research And Development Centre, Halmstad, Sweden; University Of Southern Denmark, Odense, Denmark; University Hospital of Southern Denmark, Sonderborg, Denmark.ORCID iD: 0000-0002-8081-579X
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2022 (English)In: BMC Musculoskeletal Disorders, E-ISSN 1471-2474, Vol. 23, no 1, article id 938Article in journal (Refereed) Published
Abstract [en]

Objective: Metabolic factors have been shown to be associated to severe radiographic knee osteoarthritis (RKOA). However, more knowledge is needed in early clinical knee osteoarthritis (KOA). The aim was to study associations between metabolic factors and radiographic knee osteoarthritis (OA) in individuals with knee pain. A second aim was to study associations between metabolic factors and RKOA in those with normal BMI and in those overweight/obese, respectively. Method: This cross-sectional study included 282 individuals with knee pain (without cruciate ligament injury) and aged 30–67 years, and 70% women. Waist circumference, body mass index (BMI), proportion of fat and visceral fat area (VFA) were assessed. RKOA was defined as Ahlbäck grade 1 in at least one knee. Fasting blood samples were taken and triglycerides, cholesterol (total, low density lipoprotein (LDL) and high density lipoprotein (HDL)), C-reactive protein (CRP), glucose, HbA1C were analysed. Metabolic syndrome was defined in accordance with the International Diabetes Federation (IDF). Associations were analysed by logistic regression. Results: Individuals with RKOA were older, had higher BMI, higher VFA, larger waist circumference and had increased total cholesterol, triglycerides and LDL-cholesterol, but not fasting glucose. There was no difference between the group with RKOA vs. non-radiographic group regarding the presence of metabolic syndrome. In a subgroup analysis of individuals with normal BMI (n = 126), those with RKOA had higher VFA, more central obesity, higher levels of CRP and total cholesterol, compared with individuals without RKOA. In individuals with obesity, age was the only outcome associated to RKOA. Conclusion: There were clear associations between metabolic factors and RKOA in individuals with knee pain, also in those with normal BMI. In individuals with obesity age was the only variable associated to RKOA. Trial registration:: clinicalTrials.gov Identifier: NCT04928170. © 2022, The Author(s).

Place, publisher, year, edition, pages
London: BioMed Central (BMC), 2022. Vol. 23, no 1, article id 938
Keywords [en]
Knee osteoarthritis, Knee pain, Metabolic factors
National Category
Orthopaedics
Identifiers
URN: urn:nbn:se:hh:diva-48784DOI: 10.1186/s12891-022-05881-xISI: 000876271800005PubMedID: 36307803Scopus ID: 2-s2.0-85141056952OAI: oai:DiVA.org:hh-48784DiVA, id: diva2:1717591
Funder
Swedish Rheumatism Association, R-531621, R-635431, R-939824, R-967899The Crafoord Foundation
Note

The study was funded by the Swedish Rheumatism Association, grant number R-531621, R-635431, R-939824, R-967899, Targeted investment from the Swedish Rheumatism Association – Osteoarthritis from 2014 to 2019, and the Crafoord Foundation. The funders have not influenced the study design, collection, analysis, or interpretation of data, nor the writing of the manuscript or the decision to submit the manuscript for publication. Open access funding provided by Lund University

Available from: 2022-12-09 Created: 2022-12-09 Last updated: 2024-01-17Bibliographically approved

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Andersson, Maria L.E.Haglund, EmmaAili, KatarinaBremander, AnnBergman, Stefan

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