A microfluidic platform for SAXS measurements of liquid samples Show others and affiliations
2022 (English) Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]
Small-angle X-ray scattering (SAXS) is a technique that can measure the size and shape of small particles such as proteins and nanoparticles using X-rays. At MAX IV, we are developing a microfluidic sample delivery platform to measure liquid samples containing proteins under flow using SAXS. One of the main advantages of using microfluidics is that the sample is continuously flowing, thus minimizing the risk of radiation damage as the sample is continuously refreshed. Other advantages include low sample volume and the possibility to study dynamic processes, e.g. mixing. To obtain good SAXS signals, the X-ray properties of the chip material are essential. The microfluidic chip must have low attenuation of X-rays, low background scattering, and high resistance to X-ray-induced damage, and preferably be low cost and easy to fabricate. In this work, we have evaluated the performance of two different polymer microfluidic chips for SAXS measurements.
Place, publisher, year, edition, pages 2022.
National Category
Subatomic Physics
Identifiers URN: urn:nbn:se:hh:diva-47516 OAI: oai:DiVA.org:hh-47516 DiVA, id: diva2:1686139
Conference Swedish Microfluidics in Life Science (SMILS) 2022, Uppsala, June 1-2, 2022
Projects AdaptoCell
Funder Swedish Foundation for Strategic Research, ITM-0375 2022-08-082022-08-082025-02-14 Bibliographically approved