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Health-related quality of life in adults treated for paediatric acute lymphoblastic leukaemia: a cross-sectional and longitudinal cohort study
Halmstad University, School of Health and Welfare.ORCID iD: 0000-0003-4260-7399
Halmstad University, School of Health and Welfare.ORCID iD: 0000-0001-5647-086X
Sahlgrenska University Hospital, Gothenburg, Sweden; Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sahlgrenska University Hospital, Gothenburg, Sweden; Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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2022 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 12, article id e048325Article in journal (Refereed) Published
Abstract [en]

Introduction: Acute lymphoblastic leukaemia (ALL) is the most common form of cancer in children. Although treatment methods have improved and resulted in significant improvement of survival and reduction in late effects and late mortality risk, the health-related quality of life (HRQOL) of survivors might be affected. To introduce new interventions in clinical practice with the potential to support positive HRQOL outcomes, more knowledge is needed on how HRQOL in this group is constructed and stimulated. The purpose of this study is to investigate how HRQOL is affected in adults treated for paediatric ALL, in a long-term perspective and possible factors influencing this relationship.

Methods and analysis: This cohort of young adult ALL survivors allows for investigations of factors influencing HRQOL outcomes on a national level. Eligible participants are obtained from the Swedish Childhood Cancer quality registry. Data collection includes both a follow-up of data collected in 2012 (n=224) and recruitment of new eligible participants to the cohort (n=601). The cohort will cover survivors of paediatric ALL, diagnosed between 1985 and 2007, at an age between 0 and 15 years. Data will be collected using validated, multidimensional, self-administered instruments, designed to measure HRQOL (SF-36), social support, sense of coherence and resilience.

Ethics and dissemination: The study will be carried out in accordance with the ethics permit obtained from the Swedish ethics review authority (Dnr 2019-05181). Dissemination of study results will take place through research articles and reports to the national patient organisation and the national network for consultancy nurses for this target group and to the working group for the Swedish national long-term care programme for childhood cancer. Results will also reach practical application within the follow-up clinic for adult childhood cancer survivors at Sahlgrenska Hospital in Gothenburg. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Place, publisher, year, edition, pages
London: BMJ Publishing Group Ltd, 2022. Vol. 12, article id e048325
Keywords [en]
acute lymphoblastic leukaemia, cohort, health-related quality of life, HRQOL, paediatric
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:hh:diva-46494DOI: 10.1136/bmjopen-2020-048325ISI: 000741038800003PubMedID: 34996782Scopus ID: 2-s2.0-85123271468OAI: oai:DiVA.org:hh-46494DiVA, id: diva2:1646036
Funder
Swedish Research CouncilAvailable from: 2022-03-21 Created: 2022-03-21 Last updated: 2023-08-28Bibliographically approved

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Aili, KatarinaArvidsson, SusannNygren, Jens M.

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