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Insulin resistance is associated with enhanced brain glucose uptake during euglycemic hyperinsulinemia: A large-scale PET cohort
University of Turku, Turku, Finland.ORCID iD: 0000-0003-3050-8692
University of Turku, Turku, Finland.
University of Turku, Turku, Finland.
University of Turku, Turku, Finland.
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2021 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 44, no 3, p. 788-794Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE Whereas insulin resistance is expressed as reduced glucose uptake in peripheral tissues, the relationship between insulin resistance and brain glucose metabolism remains controversial. Our aim was to examine the association of insulin resistance and brain glucose uptake (BGU) during a euglycemic hyperinsulinemic clamp in a large sample of study participants across a wide range of age and insulin sensitivity. RESEARCH DESIGN AND METHODS [18F]-fluorodeoxyglucose positron emission tomography (PET) data from 194 participants scanned under clamp conditions were compiled from a single-center cohort. BGU was quantified by the fractional uptake rate. We examined the association of age, sex,Mvalue from the clamp, steady-state insulin and free fatty acid levels, C-reactive protein levels, HbA1c, and presence of type 2 diabetes with BGU using Bayesian hierarchical modeling. RESULTS Insulin sensitivity, indexed by theMvalue, was associated negatively with BGU in all brain regions, confirming that in insulin-resistant participants BGU was enhanced during euglycemic hyperinsulinemia. In addition, the presence of type 2 diabetes was associated with additional increase in BGU. On the contrary, age was negatively related to BGU. Steady-state insulin levels, C-reactive protein and free fatty acid levels, sex, and HbA1c were not associated with BGU. CONCLUSIONS In this large cohort of participants of either sex across a wide range of age and insulin sensitivity, insulin sensitivity was the best predictor of BGU. © 2021 by the American Diabetes Association.

Place, publisher, year, edition, pages
Arlington: American Diabetes Association Inc. , 2021. Vol. 44, no 3, p. 788-794
National Category
Endocrinology and Diabetes
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URN: urn:nbn:se:hh:diva-45971DOI: 10.2337/dc20-1549ISI: 000619615700032PubMedID: 33446523Scopus ID: 2-s2.0-85102216580OAI: oai:DiVA.org:hh-45971DiVA, id: diva2:1615479
Note

The study was conducted within the Center of Excellence in Cardiovascular and Metabolic Diseases, supported by the Academy of Finland, the University of Turku, Turku University Hospital, angstrom bo Akademi University, Finnish Diabetes Foundation, Sigrid Juselius Foundation, and Finnish Cultural Foundation.

Available from: 2021-11-30 Created: 2021-11-30 Last updated: 2021-11-30Bibliographically approved

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Heinonen, Ilkka

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