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Customisable 3D printed microfluidics for integrated analysis and optimisation
Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Ashby Road, Loughborough, United Kingdom.
Department of Chemistry, Loughborough University, Epinal Way, Loughborough, United Kingdom.
School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom.
Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Ashby Road, Loughborough, United Kingdom.ORCID iD: 0000-0002-0480-4079
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2016 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 16, no 17, p. 3362-3373Article in journal (Refereed) Published
Abstract [en]

The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels. © The Royal Society of Chemistry 2016.

Place, publisher, year, edition, pages
Cambridge: Royal Society of Chemistry, 2016. Vol. 16, no 17, p. 3362-3373
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:hh:diva-37849DOI: 10.1039/C6LC00562DISI: 000382684100021Scopus ID: 2-s2.0-84983301283OAI: oai:DiVA.org:hh-37849DiVA, id: diva2:1247267
Note

Funding: Engineering and Physical Science Research Council (EPSRC) via the Centre for Innovative Manufacturing in Additive Manufacturing

Available from: 2018-09-11 Created: 2018-09-11 Last updated: 2018-09-24Bibliographically approved

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Friel, R. J.

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