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Mo-clay for treatment of psoriasis
Dept. of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Dept. of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Dept. of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID-id: 0000-0003-4360-7710
2016 (Engelska)Ingår i: Planta Medica, Stuttgart: Georg Thieme Verlag KG, 2016, Vol. 82 (S 01), artikel-id P550Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

Mo-clay was used by German doctors to treat injured soldiers' wounds during the First World War. Today, there are anecdotal cases of mo-clay being beneficial for patients suffering from psoriasis, a chronic, inflammatory disease. There are several histological features in the psoriatic skin, including acanthosis, hyperkeratosis, pararkeratosis and a loss of granular layer. Mo-clay is a unique marine deposit, an Eocene clayed diatomite. It was formed 54 million years ago from deposits of single-celled algae along with clay minerals and volcanic ash. The major elements are silicon, aluminium and iron. It is found in Denmark and Germany. As mo-clay had been used to treat wounds, it was tested for antibacterial activity. Mo-clay did not show any anti-bacterial activity against a battery of Gram-positive and -negative bacteria. Mo-clay showed stimulation of cell proliferation at concentrations 39 – 78 µg/ml in splenic mouse lymphocytes, and at 156 µg/ml in HaCat cells, whereas an inhibition of proliferation was observed at 313 µg/ml. Mo-clay was tested for anti-psoriatic activity in vivo using the mouse tail test [1]. This model can be used to investigate agents for effect on psoriasis, since the adult mouse tail has regions of both orthokeratosis and parakeratosis. Mo-clay induced orthokeratosis and showed a significant increase in epidermis thickness. The results suggest that mo-clay may have anti-psoriatic effects.

Ort, förlag, år, upplaga, sidor
Stuttgart: Georg Thieme Verlag KG, 2016. Vol. 82 (S 01), artikel-id P550
Nyckelord [en]
Mo-clay, psoriasis, mouse tail test
Nationell ämneskategori
Farmaceutiska vetenskaper
Identifikatorer
URN: urn:nbn:se:hh:diva-33670DOI: 10.1055/s-0036-1596618OAI: oai:DiVA.org:hh-33670DiVA, id: diva2:1086921
Konferens
Joint Natural Products Conference 2016, Copenhagen, Denmark, July 24-27, 2016
Tillgänglig från: 2017-04-04 Skapad: 2017-04-04 Senast uppdaterad: 2018-04-17Bibliografiskt granskad

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