hh.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.ORCID-id: 0000-0002-3576-2393
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center, Lund University, Klinikgatan 26, 221 84 Lund, Sweden.
Visa övriga samt affilieringar
2004 (Engelska)Ingår i: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 10, nr 5, s. 494-501Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Recent studies have suggested that bone marrow cells might possess a much broader differentiation potential than previously appreciated. In most cases, the reported efficiency of such plasticity has been rather low and, at least in some instances, is a consequence of cell fusion. After myocardial infarction, however, bone marrow cells have been suggested to extensively regenerate cardiomyocytes through transdifferentiation. Although bone marrow-derived cells are already being used in clinical trials, the exact identity, longevity and fate of these cells in infarcted myocardium have yet to be investigated in detail. Here we use various approaches to induce acute myocardial injury and deliver transgenically marked bone marrow cells to the injured myocardium. We show that unfractionated bone marrow cells and a purified population of hematopoietic stem and progenitor cells efficiently engraft within the infarcted myocardium. Engraftment was transient, however, and hematopoietic in nature. In contrast, bone marrow-derived cardiomyocytes were observed outside the infarcted myocardium at a low frequency and were derived exclusively through cell fusion.

Ort, förlag, år, upplaga, sidor
2004. Vol. 10, nr 5, s. 494-501
Nyckelord [en]
Animals, Cell Differentiation, Cell Fusion, Cell Movement, Graft Survival, Green Fluorescent Proteins, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Lac Operon, Luminescent Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Myocardial Infarction, Myocytes, Cardiac, Recombinant Proteins
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:hh:diva-15178DOI: 10.1038/nm1040PubMedID: 15107841Scopus ID: 2-s2.0-2442675144OAI: oai:DiVA.org:hh-15178DiVA, id: diva2:419616
Tillgänglig från: 2011-05-27 Skapad: 2011-05-27 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Nygren, Jens Martin

Sök vidare i DiVA

Av författaren/redaktören
Nygren, Jens Martin
I samma tidskrift
Nature Medicine
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 140 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf