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Steroid receptor expression and morphology in provoked vestibulodynia
Division of Obstetrics and Gynecology, Department of Clinical Sciences, Danderyd Hospital, Stockholm.
Division of Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, Stockholm.
Division of Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, Stockholm.
Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), Bio- och miljösystemforskning (BLESS), Biomekanik och biomedicin.
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2008 (Engelska)Ingår i: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 198, nr 3, s. 311.e1-311.e6Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: This study was undertaken to survey the steroid receptor expression and morphology in the vulvar vestibular mucosa in women with provoked vestibulodynia.

Study Design: Fourteen patients and 25 controls without oral contraceptives were included. Vestibular biopsy specimens were obtained and analyzed by using immunohistochemistry, followed by computerized image analysis of estrogen receptors greek small letter alpha and β, progesterone receptors A and B, glucocorticoid receptor, androgen receptor, and the proliferation marker Ki67. The morphology was estimated by measuring 4 parameters in the epithelium.

Results: There was a significantly higher expression of estrogen receptor greek small letter alpha in both the epithelium (P = .04) and the stroma (P = .02) in the patient specimens compared with the controls. There were no significant differences in the other analyses performed.

Conclusion: There is an increased expression of estrogen receptor greek small letter alpha in the vestibular mucosa but the epithelial morphology seems unaffected in women with provoked vestibulodynia. Further studies regarding plausible associations to neurogenic inflammation are needed.

Ort, förlag, år, upplaga, sidor
St. Louis: C.V. Mosby , 2008. Vol. 198, nr 3, s. 311.e1-311.e6
Nyckelord [en]
Estrogen receptor, Morphology, Provoked vestibulodynia, Vulvar mucosa
Nationell ämneskategori
Reproduktionsmedicin och gynekologi
Identifikatorer
URN: urn:nbn:se:hh:diva-1327DOI: 10.1016/j.ajog.2007.09.041ISI: 000253730000027PubMedID: 18177837Scopus ID: 2-s2.0-39649088672Lokalt ID: 2082/1706OAI: oai:DiVA.org:hh-1327DiVA, id: diva2:238545
Tillgänglig från: 2008-04-16 Skapad: 2008-04-16 Senast uppdaterad: 2018-03-23Bibliografiskt granskad

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