Background: Palliative care could be described on the four foundations which are symptom relief, cooperation, communication, and support for close relatives. Palliative care is split into two different phases where the last phase is end of life care and the main goal is to relieve suffering and improve quality of life. Nurses have a major role in supporting patients at the end-of-life care. Nursing patients at the end of their life can provide different experiences for nurses. Aim: The aim of this study was to explore nurses’ emotional experience of caring for patients in end-of-life care. Method: The chosen method was a literature review of ten qualitative scientific articles with aim to explore the current state of knowledge. Result: Several different main- and subcategories emerged in the results: The experience related to the nurse as a person: feeling of inadequacy and futility and the feeling of meaningfulness. The experience related to nursing as a professional: The need for knowledge and experience and need for teamwork and planning. Caring for patients in the end of their life can be stressful and can evoke different emotions. The feelings can be one's own thoughts about death but also feelings from the patient, relatives, and colleagues. Nurses highlighted the importance of knowledge and experience in the implementation of palliative care as well as in future care. Lack of knowledge, time and resources can affect the quality of care in a negative way by causing for example, stress or other emotional strain. Conclusion: Caring for patients in palliative care is complex and requires knowledge, experience and more research. Care at the end of life is very time consuming and becomes a big challenge for the nurses who work with patients at the end of their life, where the workload is high and the lack of time is a fact. This can contribute to feelings of guilt and inadequacy in nurses.