hh.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Response of human oral mucosa and skin to histamine provocation: laser Doppler perfusion imaging discloses differences in the nociceptive nervous system
Institute of Odontology, Karolinska Institutet, Huddinge, Sweden.
Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), Bio- och miljösystemforskning (BLESS).
Department of Physiology 1, University of Erlangen, Erlangen, Germany.
Institute of Odontology, Karolinska Institutet, P.O. Box 4064, SE-141 04 Huddinge, Sweden.
2009 (engelsk)Inngår i: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 67, nr 2, s. 99-105Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective. To investigate the existence of histamine-excitable nerve fibers in the oral mucosa and to compare the response to histamine provocation in healthy volunteers with that in a small group of patients with chronic oral pain. Material and methods. Thirteen healthy volunteers and six patients suffering from chronic oral pain took part in the study. Blood perfusion was monitored in the hard palate, the tongue, and the skin of the cheek using laser Doppler perfusion imaging (Perimed; Sweden). Baseline scannings were performed, followed by 15 scannings after iontophoresis of histamine (1%). A free description of the sensations was then obtained from the participants after finishing the measurements. Results. Compared to pre-histamine scanning, histamine application resulted in a considerable increase in blood perfusion in all regions (p0.001) that was significantly higher in skin than in oral mucosa (p0.001). There were no significant differences between the healthy volunteers and the patients regarding baseline blood flow, increased blood perfusion, or flare size after histamine provocation. The sensory impression was reported to be more persistent and intense in the skin than in the oral mucosa. No effect on mucosa could be detected by visual inspection. Conclusions. Intra-oral flare could be induced by activating histamine-excitable nerve fibers. Both duration and intensity of the flare were considerably less pronounced than in the control skin site. Histamine application was not clearly associated with itch.

sted, utgiver, år, opplag, sider
London: Taylor & Francis, 2009. Vol. 67, nr 2, s. 99-105
Emneord [en]
Axon reflex, histamine-excitable nerve fibers, laser-Doppler perfusion imaging, nociceptors, oral pain
HSV kategori
Identifikatorer
URN: urn:nbn:se:hh:diva-18912DOI: 10.1080/00016350802698622ISI: 000263366500006PubMedID: 19137455Scopus ID: 2-s2.0-60549083348OAI: oai:DiVA.org:hh-18912DiVA, id: diva2:537263
Tilgjengelig fra: 2012-06-26 Laget: 2012-06-25 Sist oppdatert: 2018-03-22bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Hilliges, Marita

Søk i DiVA

Av forfatter/redaktør
Hilliges, Marita
Av organisasjonen
I samme tidsskrift
Acta Odontologica Scandinavica

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 111 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf