AdaptoCell – Microfluidic Platforms at MAX IV LaboratoryShow others and affiliations
2021 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]
In the AdaptoCell project, we are developing microfluidic platforms for X-ray studies of liquid samples. Microfluidics is a suitable technology for samples that are prone to radiation damage, such as proteins. By having the sample underflow, the sample is continuously refreshed, and the risk of radiation damage is reduced. The technology is also suitable for investigating dynamic events such as in situ mixing. The microfluidic platforms are being integrated at three beamlines at MAX IV Laboratory: Balder (X-ray absorption/emission spectroscopy), CoSAXS (small angle x-ray scattering) and MicroMAX (serial synchrotron crystallography). Currently, the platforms are available for users at Balder and CoSAXS, which is under development at MicroMAX. In addition, we also provide a microfluidic offline test station where users can test their samples and optimise their devices before the beam time. The main components of the microfluidic setup are the pressure-driven flow controller and the microfluidic chip. We mainly use commercially available polymer microfluidic chips made of COC (cyclic olefin copolymer). COC is used as a chip material as it has high X-ray transmission and high resistance to radiation damage. There are several different chip designs available such as straight channel chips, droplet generator chips and mixing chips. We believe the AdaptoCell platforms will be useful and versatile sample environments for academic and industrial users at MAX IV Laboratory who want to perform experiments with liquid samples under flow.
Place, publisher, year, edition, pages
2021.
National Category
Subatomic Physics
Research subject
Smart Cities and Communities
Identifiers
URN: urn:nbn:se:hh:diva-47662OAI: oai:DiVA.org:hh-47662DiVA, id: diva2:1686171
Conference
33rd MAX IV User Meeting, 25-27 Oct., 2021
Projects
AdaptoCell
Funder
Swedish Foundation for Strategic Research, ITM-03752022-08-082022-08-082025-02-14Bibliographically approved