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Andersson, Åsa, ProfessorORCID iD iconorcid.org/0000-0003-4360-7710
Publications (10 of 18) Show all publications
Varga, T. V., Andersson, Å., Lauruschkus, K. & Tornberg, Å. B. (2023). Acute and Long-Term Changes in Blood-Borne Biomarkers in Response to Dynamic Standing in Nonambulant Children With Cerebral Palsy. Pediatric Exercise Science, 1-8
Open this publication in new window or tab >>Acute and Long-Term Changes in Blood-Borne Biomarkers in Response to Dynamic Standing in Nonambulant Children With Cerebral Palsy
2023 (English)In: Pediatric Exercise Science, ISSN 0899-8493, E-ISSN 1543-2920, p. 1-8Article in journal (Refereed) Epub ahead of print
Abstract [en]

Purpose: To investigate acute and long-term changes in hormonal and inflammatory biomarkers in nonambulant children with cerebral palsy in response to dynamic standing exercise.

Methods: Fourteen children with severe cerebral palsy were recruited. Anthropometrics and body composition measures were obtained. Physical activity levels before the study were assessed using hip-worn accelerometry. All children underwent a 30-minute dynamic standing exercise using the Innowalk standing aid. Respiratory data during exercise were collected using indirect calorimetry. Blood samples were collected before and after exercise. Blood samples were also obtained after two 16-week exercise protocols, in a resting state. Hormonal and inflammatory metabolites were measured from blood serum/plasma, and acute and long-term changes in biomarker levels were assessed using Wilcoxon signed-rank tests.

Results: Of the 14 children at baseline, all had slightly/moderately/severely elevated C-reactive protein and cortisol levels. C-reactive protein levels were decreased following a 30-minute bout of dynamic standing (before exercise: 53 mg/L [interquartile range: 40-201]; after exercise: 39 mg/L [interquartile range: 20-107]; P = .04).

Conclusions: We show that several hormonal and inflammatory biomarkers are dysregulated in children with cerebral palsy. Our preliminary results from a small, but deep-phenotyped prospective cohort indicate acute and long-term alterations of several biomarkers in response to exercise. ©2023TheAuthors.

Place, publisher, year, edition, pages
Champaign, IL: Human Kinetics, 2023
Keywords
exercise physiology, hormones, inflammation, rehabilitation
National Category
Physiotherapy Sport and Fitness Sciences Cell and Molecular Biology
Research subject
Health Innovation; Health Innovation, M4HP - Movement for health and performance
Identifiers
urn:nbn:se:hh:diva-51313 (URN)10.1123/pes.2022-0093 (DOI)001037011200001 ()37433523 (PubMedID)
Funder
Swedish Research CouncilSwedish Research Council FormasVinnova
Available from: 2023-08-17 Created: 2023-08-17 Last updated: 2023-11-17Bibliographically approved
Torell, A., Olsson, M. C., Andersson, Å., Malm, K., Åberg, I., Wiking, E. & Haglund, E. (2023). Effects of a digital-based high-intensity interval training (HIIT) intervention in individuals with axial spondyloarthritis: – a randomized controlled pilot study (RCT). In: : . Paper presented at Reumadagarna 14-16 september 2023.
Open this publication in new window or tab >>Effects of a digital-based high-intensity interval training (HIIT) intervention in individuals with axial spondyloarthritis: – a randomized controlled pilot study (RCT)
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2023 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Background

Physical exercise is an important treatment for individuals with axial spondyloarthritis (axSpA). Although high-intensity training (HIT) has been shown to reduce disease symptoms and risk of comorbidity without exacerbating disease activity (1), compliance tends to decrease over time. Increased knowledge is needed on how to optimize and tailor individual exercise programs for continued regular exercising and improved health.

Objective

To study the effects of HIT on aerobic capacity, body composition, disease activity, physical function, health status and fatigue in individuals with axSpA after a 12-week intervention supported by digital coaching.

Methods

Twenty-two individuals (women, n=12), recruited from two rheumatology clinics in southern Sweden, were randomized to a HIT intervention group (HG; n=11) or a control group (CG; n=11). The HG completed three HIT sessions/week, including two interval training sessions (4x4 min), in self-selected activities for 12 weeks. The individuals in the HG were individually coached and had regular support from a physical therapist primarily by digital coaching. The CG continued exercising as usual. Assessment of aerobic capacity (VO2max), body composition (BMI and visceral fat area [cm2]), disease activity (CRP [µg/ml], BASDAI, 0-10 best-worst), physical function (BASFI, 0-10 best-worst), health status (EQ5D, 0-1 worst-best, ASAS health index [ASAS-HI], 0-17 best-worst), and fatigue (fatigue severity scale [FFS], 0-7 best-worst) were sampled at baseline and after 12 weeks. Mean and standard deviation (SD) were used for descriptive statistics. Repeated measures analysis of variance (ANOVA) was used to investigate effect of group (HG*CG) and time (PRE*POST), with a post-hoc analysis using t-tests when ANOVA indicated a significant difference in main effects or interactions. A significance level of p≤0.05 was used. Fisher´s exact test was used to study the effects over time for CRP (as dichotomized variable, > or < 4 µg/ml).

Results

Results presented are part of an ongoing RCT based on 19 individuals (women n=11) that have completed the 12-week follow-up analyses. The participants mean (SD) age was 48 (10) years, BMI 25 (4), VO2max 37 (6) mlO2/kg/min, and BASDAI 2.6 (0.3). No differences were present between the HG (n=9) and the CG group (n=10) at baseline for the studied variables. After 12 weeks of HIT an ANOVA interaction (p<0.05 showed that HG increased their VO2max (6.4 [3.6] mlO2/kg/min; p<0.001) but CG did not. For BMI, visceral fat area, disease activity (BASDAI), physical function (BASFI), fatigue (FFS) no differences in main effects or interactions were found (p>0.05). Health status (EQ5D) showed an ANOVA time main effect (p=0.007) where the HG increased their health status (0.10 [0.06] units; p=0.02) after 12-weeks, but CG did not. For health status measured with ASAS-HI no differences between groups were found. For dichotomized CRP-values no differences were found in either of the group’s pre-post. 

Conclusions

This pilot RCT shows that after 12 weeks of digital-based HIT intervention, the HG increased their aerobic capacity and EQ5D health status compared to CG, while body composition, disease activity, physical function, and fatigue did not show any significant differences between the groups. 

References

(1)    Sveaas SH, Bilberg a, Berg IJ, Provan SA, Rollefstad S, Semb AG, et al. high intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): a multicentre randomised trial of 100 patients. Br J Sports med. 2019

Acknowledgement

Thanks to participating patients, to patient partner Åsa Fiskaare and for contributions from the Swedish Rheumatism Association, Stig Thunes Foundation and Norrbacka Eugenia Foundation, Sweden

National Category
Medical and Health Sciences
Research subject
Health Innovation, M4HP
Identifiers
urn:nbn:se:hh:diva-52586 (URN)
Conference
Reumadagarna 14-16 september 2023
Available from: 2024-02-08 Created: 2024-02-08 Last updated: 2024-02-08
Torell, A., Olsson, M. C., Andersson, Å., Malm, K., Åberg, I., Wiking, E. & Haglund, E. (2023). Effects of a digital-based high-intensity training intervention in individuals with axial spondyloarthritis – a randomized controlled pilot study (RCT). Paper presented at EULAR 2023 European Congress of Rheumatology, Milan, Italy, 31 May - 3 June, 2023. Annals of the Rheumatic Diseases, 82(Suppl 1), 1049-1049
Open this publication in new window or tab >>Effects of a digital-based high-intensity training intervention in individuals with axial spondyloarthritis – a randomized controlled pilot study (RCT)
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2023 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, Vol. 82, no Suppl 1, p. 1049-1049Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
London: BMJ Publishing Group Ltd, 2023
National Category
Rheumatology and Autoimmunity
Research subject
Health Innovation, M4HP - Movement for health and performance; Health Innovation
Identifiers
urn:nbn:se:hh:diva-51823 (URN)10.1136/annrheumdis-2023-eular.3460 (DOI)
Conference
EULAR 2023 European Congress of Rheumatology, Milan, Italy, 31 May - 3 June, 2023
Funder
Swedish Rheumatism AssociationNorrbacka-Eugenia Foundation
Available from: 2023-10-13 Created: 2023-10-13 Last updated: 2023-10-24Bibliographically approved
Lundström, P., Lauruschkus, K., Andersson, Å. & Tornberg, Å. B. (2022). Acute Response to One Bout of Dynamic Standing Exercise on Blood Glucose and Blood Lactate Among Children and Adolescents With Cerebral Palsy Who are Nonambulant. Pediatric Exercise Science, 34(2), 93-98
Open this publication in new window or tab >>Acute Response to One Bout of Dynamic Standing Exercise on Blood Glucose and Blood Lactate Among Children and Adolescents With Cerebral Palsy Who are Nonambulant
2022 (English)In: Pediatric Exercise Science, ISSN 0899-8493, E-ISSN 1543-2920, Vol. 34, no 2, p. 93-98Article in journal (Refereed) Published
Abstract [en]

Purpose: To investigate the acute exercise effects of dynamic standing exercise (DyS) on blood glucose and blood lactate among children and adolescent with cerebral palsy (CP) who are non-ambulant. 

Methods: Twenty-four participants with CP who are non-ambulant performed 30 minutes of DyS using a motorized device enabling assisted passive movements in an upright weight-bearing position. Capillary blood-samples were taken from the fingertip for measurement of blood glucose and blood lactate at rest and at the end of exercise. 

Results: At rest, the participants had hyperlactatemia that was unaffected after exercise presented as median and interquartile range at rest 1.8 [1.3:2.7] mmol/L and after exercise 2.0 [1.1:2.5] mmol/L. Children and adolescents with GMFCS-E&R V had higher lactate levels at rest (2.5 [1.8:2.9] vs 1.4 [1.0:2.0]; p=0.030) and after exercise (2.3 [2.0:2.6] vs 1.2 [0.9:2.2]; p=0.032) compared to children and adolescents with GMFCS-E&R IV respectively. A statistically significant larger decrease in blood lactate levels after exercise was observed in children and adolescents with higher resting blood lactate levels (rho=0.56;p=0.004). There were no statistically significant changes in blood glucose. 

Conclusions: Forty percent of the participants had mild hyperlactatemia at rest and participants with the highest blood lactate levels at rest had the greatest decrease in blood lactate levels after one bout of exercise. Children and adolescents with classified into higher level of GMFCS-E&R had higher blood lactate levels. More studies are needed on how to prevent chronically high resting levels of lactate with exercise in children with CP who are non-ambulant. 

Place, publisher, year, edition, pages
Champaign, IL: Human Kinetics, 2022
Keywords
Anaerobic metabolism, Hyperlactatemia, Physical activity, Skeletal muscle, Secondary muscle pathology
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:hh:diva-45809 (URN)10.1123/pes.2021-0098 (DOI)000799177400005 ()35016158 (PubMedID)2-s2.0-85130644578 (Scopus ID)
Funder
Swedish Research Council, 2018–2433Linnéa och Josef Carlssons stiftelse
Note

Funding: The Swedish Research Council (2018–2433), the Swedish National Association for Disabled Children and Young People, the Linnea and Joseph Carlsson Foundation, the Promobila Foundation, and the Foundation of aid to disabled in Skåne.

Available from: 2021-10-29 Created: 2021-10-29 Last updated: 2022-06-22Bibliographically approved
Andersson, Å., Haglund, E., Berthold, E., Mogard, E., Torell, A. & Olsson, M. C. (2022). Serum Protein Response To A Single High-Intensity Interval Training Bout – Comparison Between Individuals With Spondyloarthritis And Healthy Controls. Paper presented at EULAR 2022, Copenhagen, Denmark, 1-4 June, 2022. Annals of the Rheumatic Diseases, 81(Suppl 1), 780-781
Open this publication in new window or tab >>Serum Protein Response To A Single High-Intensity Interval Training Bout – Comparison Between Individuals With Spondyloarthritis And Healthy Controls
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2022 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 81, no Suppl 1, p. 780-781Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
London: BMJ Publishing Group Ltd, 2022
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:hh:diva-47543 (URN)10.1136/annrheumdis-2022-eular.4984 (DOI)000850279003083 ()
Conference
EULAR 2022, Copenhagen, Denmark, 1-4 June, 2022
Available from: 2022-07-04 Created: 2022-07-04 Last updated: 2023-08-21Bibliographically approved
Andersson, Å. & Sardar, S. (2019). A transcriptional regulator controlling severity in experimental arthritis. Paper presented at Annual European Congress of Rheumatology, EULAR 2019, Madrid, Spain, June 12-15, 2019. Annals of the Rheumatic Diseases, 78(Suppl. 2), 667-667, Article ID FRI0011.
Open this publication in new window or tab >>A transcriptional regulator controlling severity in experimental arthritis
2019 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 78, no Suppl. 2, p. 667-667, article id FRI0011Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background: Susceptibility to Rheumatoid Arthritis (RA) is dependent on complex interactions among genetic and environmental factors. Protein candidates and their role in pathways leading to chronic inflammation of the joints, in addition to their potential as drug targets, can be revealed with the help of experimental models for disease (1). From the results of functional genetic studies, we have recently shown that the T-box gene, TBX3, is a candidate gene in Collagen Induced Arthritis (CIA), an experimental model for RA (2). TBX3 encodes a transcriptional regulator involved in differentiation of several organs, including bone, during embryonic development. It has, in addition, been demonstrated important in oncogenesis (3). Our studies suggest that TBX3 has a role in B-cell activation and is important for the severity of disease in the CIA model (2). Objectives: The objective of this project is to understand the role for the transcriptional regulator TBX3 in development of RA. Methods: Bioinformatics based comparative studies of mouse and human alleles in the regulatory region of TBX3. CRISPR/Cas9-introduced deletions and base modifications in human B-cell lines. Activation of genetically modified B-cells in vitro, followed by analyses of proliferative response and antibody production. Results: Studies of CIA development in mice with single nucleotide polymorphisms (SNPs) in the regulatory region of Tbx3 revealed a significant difference in severity of arthritis. In line with this, the anti-collagen type II antibody titers were shown substantially higher in mice with more severe arthritis, even before onset of disease. In addition, preliminary data shows that the proliferative response to Type II collagen upon re-challenge of lymph node cells in vitro is higher in these mice, suggesting a more active response to the disease-inducing antigen. Because the TBX3 gene is conserved between mouse and human, we are investigating whether similar genetic variations are found in the regulatory region of the human TBX3 gene and whether the putative genetic variation would lead to a distinct B-cell phenotype upon activation in vitro. Conclusion: We suggest that the oncoprotein TBX3 is a novel candidate contributing to disease severity in experimental arthritis. Investigations of genetic variation in the TBX3 gene and its role in the activation of human B-cells will reveal whether this protein is a candidate for influencing also development of RA.

Place, publisher, year, edition, pages
London, UK: BMJ Publishing Group Ltd, 2019
Keywords
Rheumatoid Arthritis, Collagen-induced arthritis, TBX3, transcriptional regulator, biomarker
National Category
Immunology in the medical area
Identifiers
urn:nbn:se:hh:diva-39950 (URN)10.1136/annrheumdis-2019-eular.7057 (DOI)000472207102055 ()
Conference
Annual European Congress of Rheumatology, EULAR 2019, Madrid, Spain, June 12-15, 2019
Available from: 2019-06-23 Created: 2019-06-23 Last updated: 2020-05-07Bibliographically approved
Olsson, M. C., Fälth, J., Ahlebrand, A., Andersson, Å. & Haglund, E. (2019). Bench press muscle activation with triceps brachii pre-exhaustion in females and males. Paper presented at BASES Conference 2019, Leicester, United Kingdom, November 19-20, 2019. Journal of Sports Sciences, 37(Supp1), 71-72, Article ID D2.P6..
Open this publication in new window or tab >>Bench press muscle activation with triceps brachii pre-exhaustion in females and males
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2019 (English)In: Journal of Sports Sciences, ISSN 0264-0414, E-ISSN 1466-447X, Vol. 37, no Supp1, p. 71-72, article id D2.P6.Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
Abingdon: Routledge, 2019
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:hh:diva-41063 (URN)10.1080/02640414.2019.1671688 (DOI)
Conference
BASES Conference 2019, Leicester, United Kingdom, November 19-20, 2019
Available from: 2019-12-02 Created: 2019-12-02 Last updated: 2019-12-10Bibliographically approved
Aksel Jacobsen, F. & Andersson, Å. (2019). Inhibitors of intracellular enzymes for treatment of multiple sclerosis. Atlas of Science
Open this publication in new window or tab >>Inhibitors of intracellular enzymes for treatment of multiple sclerosis
2019 (English)In: Atlas of ScienceArticle, review/survey (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
AoS Nordic AB, 2019
Keywords
MS, EAE, tyrosin kinase inhibitors, lymphocytes
National Category
Immunology in the medical area
Identifiers
urn:nbn:se:hh:diva-39376 (URN)
Available from: 2019-05-17 Created: 2019-05-17 Last updated: 2019-08-06Bibliographically approved
Sardar, S., Kerr, A., Vaartjes, D., Moltved, E. R., Karosiene, E., Gupta, R. & Andersson, Å. (2019). The oncoprotein TBX3 is controlling severity in experimental arthritis. Arthritis Research & Therapy, 21(1), Article ID 16.
Open this publication in new window or tab >>The oncoprotein TBX3 is controlling severity in experimental arthritis
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2019 (English)In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 21, no 1, article id 16Article in journal (Refereed) Published
Abstract [en]

Background: Development of autoimmune diseases is the result of a complex interplay between hereditary and environmental factors, with multiple genes contributing to the pathogenesis in human disease as well as in experimental models for disease. The T-box protein 3 is a transcriptional repressor essential during early embryonic development, in the formation of bone and additional organ systems, and in tumorigenesis.

Methods: With the aim to find novel genes important for autoimmune inflammation, we have performed genetic studies of collagen-induced arthritis, a mouse experimental model for Rheumatoid Arthritis.

Results: We show that a small genetic fragment on mouse chromosome 5, including Tbx3 and three additional protein-coding genes, is linked to severe arthritis and high titers of anti-collagen antibodies. Gene expression studies have revealed differential expression of Tbx3 in B-cells, where low expression was accompanied by a higher B-cell response upon B-cell receptor stimulation in vitro. Furthermore, we show that serum TBX3 levels rise concomitantly with increasing severity of CIA.

Conclusions: From these results, we suggest that TBX3 is a novel factor important for the regulation of gene transcription in the immune system and that genetic polymorphisms, resulting in lower expression of Tbx3, are contributing to a more severe form of collagen-induced arthritis and high titers of autoantibodies. We also propose TBX3 as a putative diagnostic biomarker for rheumatoid arthritis.

Place, publisher, year, edition, pages
London: BioMed Central, 2019
Keywords
Collagen-induced arthritis, transcriptional regulation, TBX3, TBX5, biomarker, Eae39r
National Category
Immunology in the medical area
Identifiers
urn:nbn:se:hh:diva-38630 (URN)10.1186/s13075-018-1797-3 (DOI)000455453800003 ()30630509 (PubMedID)2-s2.0-85059817411 (Scopus ID)
Note

Funding: The Danish Rheumatism Association, The AP Møller Research grant for Medical Science and The Oticon foundation

Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2020-02-03Bibliographically approved
Aksel Jacobsen, F., Scherer, A. N., Mouritsen, J., Bragadóttir, H., Bäckström, B. T., Sardar, S., . . . Andersson, Å. (2018). A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation. Journal of Neuroimmune Pharmacology, 13(2), 265-276
Open this publication in new window or tab >>A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation
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2018 (English)In: Journal of Neuroimmune Pharmacology, ISSN 1557-1890, E-ISSN 1557-1904, Vol. 13, no 2, p. 265-276Article in journal (Refereed) Published
Abstract [en]

Multiple sclerosis is a neuroinflammatory degenerative disease, caused by activated immune cells infiltrating the CNS. The disease etiology involves both genetic and environmental factors. The mouse genetic locus, Eae27, linked to disease development in the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis, was studied in order to identify contributing disease susceptibility factors and potential drug targets for multiple sclerosis. Studies of an Eae27 congenic mouse strain, revealed that genetic variation within Eae27 influences EAE development. The Abl2 gene, encoding the non-receptor tyrosine kinase Arg, is located in the 4,1 megabase pair long Eae27 region. The Arg protein plays an important role in cellular regulation and is, in addition, involved in signaling through the B- and T-cell receptors, important for the autoimmune response. The presence of a single nucleotide polymorphism causing an amino acid change in a near actin-interacting domain of Arg, in addition to altered lymphocyte activation in the congenic mice upon immunization with myelin antigen, makes Abl2/Arg a candidate gene for EAE. Here we demonstrate that the non-synonymous SNP does not change Arg’s binding affinity for F-actin but suggest a role for Abl kinases in CNS inflammation pathogenesis by showing that pharmacological inhibition of Abl kinases ameliorates EAE, but not experimental arthritis. © 2018 The Author(s)

Place, publisher, year, edition, pages
New York, NY: Springer-Verlag New York, 2018
Keywords
Abl kinase, Arg, Eae27, Experimental autoimmune encephalomyelitis, Imatinib
National Category
Immunology in the medical area
Identifiers
urn:nbn:se:hh:diva-36440 (URN)10.1007/s11481-018-9783-8 (DOI)000431210500012 ()29550892 (PubMedID)2-s2.0-85044043378 (Scopus ID)
Note

Funding: Novo Nordisk, Denmark; SHARE (Synergy in human and animal research) University of Copenhagen; The Warwara Larsen Foundation, The Carlsberg Foundation; The Karen A. Tolstrup Foundation; The A.P. Møller Foundation.

Available from: 2018-03-16 Created: 2018-03-16 Last updated: 2020-02-03Bibliographically approved
Projects
Study on an oncoprotein and its role in rheumatoid arthritis [R-855081]
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-4360-7710

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